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Morton and Jackson adopted the use of anesthesia for dental purposes, while Long administered it for minor surgeries. The usual scheme of generic drug appearance is the following: - a big pharmaceutical company invests a lot of money in research and development of a new drug; - if they are successful, they invest more money into clinical trials and marketing promotion; - in order to assure their return on investment, the company receives exclusive rights to sell the product under a single brand name for a specified period of time in specified areas; - generic drug manufacturers receive the exact formulation of the new drug and by employing low cost labor and accessible raw materials with no need to research and develop anything new, start producing the exact chemical copy of the branded drug; - generic drugs are sold only in countries where the license of the branded drug is not in force In the 1800s, Crawford Long, William Morton, Charles Jackson and Horace Wells all discovered that breathing in ether or nitrous oxide could suppress pain.

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